Naoyuki Inagaki

This study validates the adhesion-clutch mechanism in 3D environments by showing that N-cadherin and shootin1a drive axon outgrowth when present in an appropriate adhesive substrate.

The paper shows actin filaments move directionally via treadmilling, driving membrane protrusions and cell migration through physical mechanisms.

The paper establishes mechanical polarity as a physical principle linking adhesion dynamics to directional stability in glioblastoma cell migration.

The paper identifies a weak, integrin-independent adhesion-clutch mechanism involving shootin1 and L1 that enables rapid cell migration and glioblastoma motility by transmitting weak traction forces.

This study shows that netrin-1-induced axonal haptotaxis is mediated by mechanical coupling between netrin-1 and its receptor DCC, facilitated by shootin1a and actin flow.