Kimberly Kay Leslie

This study shows auranofin enhances cisplatin response in endometrial cancer by modulating NOTCH signaling, with context-dependent effects on tumor models.

This study shows curcumin analogues HO-3867 and AKT-100 induce HMOX1-mediated ferroptosis and apoptosis, effectively inhibiting endometrial cancer cell growth.

This paper develops AKT-100, a curcumin analogue that targets mutant p53 and STAT3 in gynecologic cancer cells, showing cytotoxicity and synergy with existing therapies.

The paper describes an automated live-cell imaging method to assess drug responses in patient-derived organoid models, demonstrating its ability to quantify cell health and apoptosis over time.