NeurosciencebioRxivPreprint
RNA Editing of DEGS1 Links Genetic Risk to Ceramide Dysregulation and Astrocyte Toxicity in ALS
DOI 10.64898/2026.09.17.752108
Author
Steve Rodriguez
Harvard UniversityORCID 0000-0002-2708-5791Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 31 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- NeurosciencebioRxivPreprint
TYK2 as a novel therapeutic target in Alzheimer Disease
Laura E. König, Steve Rodriguez, Clemens B. Hug…·Mark W. Albers
The paper identifies TYK2 as a potential therapeutic target for neurodegenerative diseases by linking cdsRNA-induced inflammation to interferon signaling and demonstrating protective effects of TYK2 inhibitors.
6 citations - NeuroscienceNature CommunicationsPeer-reviewed
Machine Learning Identifies Novel Candidates for DrugRepurposing in Alzheimer's Disease
Steve Rodriguez, Clemens B. Hug, Petar V. Todorov…·Artem Sokolov
The paper presents a machine learning framework to identify FDA-approved drugs for repurposing in Alzheimer's Disease by analyzing gene lists associated with disease severity and molecular mechanisms.
299 citationstop 1% - NeurosciencebioRxivPreprint
Genome-encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death
Steven Rodriguez, Benjamin R. Schrank, Aslı Şahin…·Mark W. Albers
The paper shows that cytoplasmic double-stranded RNA (cdsRNA) from C9ORF72 expansions in ALS-FTD brains triggers IFN-I signaling and neuronal death through a viral-mimetic mechanism.
5 citations