Drew T. Dunham

The paper shows that restricted phage infection primes bacterial immunity to defeat counterdefenses by increasing defense protein abundance and altering host-phage stoichiometry.

This paper identifies how the phage-encoded inhibitor OrbA disrupts the BREX defense system in Vibrio cholerae by directly binding to the BrxC ATPase component.

The paper shows that H-NS and TsrA regulate horizontally acquired elements in a clinical isolate of V. cholerae, with TsrA modulating H-NS activity and independently affecting gene expression.

The paper examines HEGs in bacteriophages, finding variable distribution, HEG islands, and domain swapping, suggesting HEGs significantly influence phage evolution.