Scalable fold-change estimation from microbial metagenomics
The paper introduces fastEmu, a scalable method for estimating differential abundance in microbial metagenomics data, achieving faster runtime with minimal impact on error rates.
Author
University of WashingtonORCID 0000-0002-2802-4317Unclaimed ORCID profile · follow to get notified of new preprints
13 papers
Recent·Most cited
The paper introduces fastEmu, a scalable method for estimating differential abundance in microbial metagenomics data, achieving faster runtime with minimal impact on error rates.
Pauline Trinh, David S. Clausen, Amy D. Willis
happi tests gene enrichment hypotheses while accounting for genome quality in metagenome-assembled genomes.
Sarah Teichman, Michael Lee, Amy D. Willis
The paper introduces an interactive method for analyzing gene-level phylogenies in microbial evolution, enabling visualization and comparison of gene histories across bacterial strains.
Pauline Trinh, Marilyn C. Roberts, Peter MacGarr Rabinowitz, Amy D. Willis
The paper compares gut metagenomes of dairy workers and community controls to assess antibiotic resistance and pathogen exposure risks.
Michael R. McLaren, Jacob T. Nearing, Amy D. Willis…·Benjamin J. Callahan
The paper examines how taxonomic bias affects differential-abundance analysis in microbiome studies and proposes methods to mitigate its effects.
Taylor E. Reiter, Luiz C. Irber, Alicia A. Gingrich…·C. Titus Brown
The paper identifies five bacterial strains associated with Crohn's disease using a novel method combining machine learning and assembly graphs for metagenomic analysis.
Emily Kuehn, David S. Clausen, Ryan W. Null…·B. Duygu Özpolat
The paper investigates how segment number thresholds influence germline cluster proliferation and gametogenesis in juvenile Platynereis dumerilii, finding a correlation between growth state and developmental stages.
Brian D. Williamson, James P. Hughes, Amy D. Willis
The paper proposes a method to estimate absolute microbial abundances using both relative and absolute abundance data, improving accuracy by accounting for detection efficiencies.
Samuel S. Minot, Kevin C. Barry, Caroline Kasman…·Amy D. Willis
The paper introduces a tool for gene-level metagenomic analysis to identify genomic islands linked to immunotherapy response in microbiome data.
Jean Feng, William S. DeWitt, Aaron McKenna…·Frederick A. Matsen IV
This paper introduces a statistical model and method for estimating cell lineage trees using maximum-likelihood phylogenetics, showing improved accuracy over existing methods in simulations and zebrafish development.
DivNet estimates diversity in networked communities, improving alpha- and beta-diversity accuracy by incorporating ecological interactions, especially in high-diversity ecosystems.
Michael R. McLaren, Amy D. Willis, Benjamin J. Callahan
The paper identifies and corrects systematic bias in metagenomic sequencing by modeling how bias distorts measurements and validating it across different protocols and datasets.
Samuel S. Minot, Amy D. Willis
The paper introduces a computational method to cluster microbial genes by co-abundance, identifying reproducible gene groups linked to colorectal cancer and inflammatory bowel disease.