Somya Mani

The paper shows that irreversible differentiation programs are common due to their association with stability and robustness, not direct selection.

This study links tissue morphology and healing capacity using a cell-fate model, showing that only tissues with large contiguous domains can heal from injuries.

The paper uses a generative model to analyze developmental programs and finds that cell-type lineage graphs are rarely tree-like and often involve regeneration through pluripotent cells.