Ajeet K. Sharma

The paper introduces a computational framework linking chromatin structure to gene regulation using polymer models and Hi-C data, showing how CTCF deletion affects gene expression in limb development.

The paper develops chemical kinetic methods to measure translation initiation, elongation, and codon-specific rates from ribosome profiling data, finding significant variability in codon translation rates.

The paper shows that two slow codon clusters can increase mRNA half-life by suppressing ribosome queues, contrasting the effect of a single cluster.