NeurosciencebioRxivPreprint
Circadian phosphotimer generates time cues through PER dimerization-mediated trans-phosphorylation
Kwangjun Lee, Jiyoung Park, Junghyun Lee…·Choogon Lee
The paper shows that PER dimerization-mediated trans-phosphorylation generates time cues for circadian rhythms, and disrupts it shortens the circadian period and advances sleep cycles in mice.
DOI 10.1101/2025.10.01.679838