Jesse A. Sharp

This paper reviews optimal control theory in systems biology, implements the forward-backward sweep method, and accelerates its convergence using existing techniques.

The paper develops a theoretical framework for understanding bacterial persistence as a hedging strategy by integrating optimal control theory from finance and mathematical biology.

This paper applies optimal control theory to design combination therapies for acute myeloid leukaemia by analyzing control dynamics and pay-off functions.

This paper develops optimal chemotherapy strategies for AML by incorporating immune response into a stem cell model and applying optimal control theory.