Jeroen J.M. Hoozemans

The paper identifies genetic variants associated with protein abundance and altered protein-protein correlations in the Gyrus Temporalis Medius in Alzheimer's Disease patients.

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

This study uses single-nucleus and spatial transcriptomics to identify cell type-specific associations with Alzheimer's disease pathology in human temporal cortex and white matter.

This study examines how Alzheimer's disease pathology in dementia with Lewy bodies correlates with astroglial α-synucleinopathy and regional differences in pathology load and morphology.

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

FibrilPaint1 measures Tau amyloid fibril length in fluids using fluorescence and microfluidics, enabling diagnostic and research applications in neurodegenerative diseases.

This study identifies histopathological correlates of MRI cortical atrophy in Alzheimer's disease, finding that phosphorylated-tau and reactive microglia loads strongly correlate with atrophy in specific brain regions.

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

This study examines neuropathological hallmarks in centenarians' brains and their association with cognitive performance, finding that some pathologies correlate with lower cognitive test results.

The paper identifies two VH5-51/VL4-1 antibodies that recognize a common tau antigenic motif and have distinct functionalities in blocking tau aggregation and mediating microglial uptake.