Françoise A. Dekker

This paper introduces FibrilPaints, a modular peptide system for selective amyloid binding and manipulation, showing that sequence variations affect binding affinity while allowing functional modifications.

This paper introduces FibrilPaint peptides that selectively bind and track HttEx1Q44 amyloid fibrils, enabling monitoring of fibril growth and molecular targeting through ubiquitination.

The paper demonstrates that FP20 recruits the ubiquitin-proteasome system to Tau amyloid fibrils, enabling their degradation and offering a strategy for targeting amyloid diseases.

FibrilPaint1 measures Tau amyloid fibril length in fluids using fluorescence and microfluidics, enabling diagnostic and research applications in neurodegenerative diseases.