BioengineeringCell Reports MedicinePeer-reviewed
Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics
Rachel P. Wallace, Kirsten C. Refvik, Jennifer T. Antane…·Jeffrey A. Hubbell
This study shows that conjugating immunogenic biologics to a synthetic mannose polymer reduces anti-drug antibody responses by impairing T cell and B cell responses.
15 citations