Priscilla F. McAuliffe

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.

The paper identifies S100A11 as a factor promoting macrophage recruitment in ER+ breast cancer through single-cell RNA-sequencing analysis and functional experiments.

This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.