Osama Shiraz Shah

The paper identifies increased GPCR pathway activity in breast cancer ovarian metastases and links it to migration and F-actin reorganization through CaSR.

This study identifies and characterizes patient-derived xenograft models of invasive lobular breast carcinoma using multi-omics and histopathology, finding seven ILC PDX models with CDH1 mutations and low CDH1 expression.

This study investigates FGFR4's role in endocrine resistance in ER+ breast cancer and finds it does not generally mediate resistance, though HER2-like subtypes may respond to FGFR4 inhibition.

The paper characterizes ILC and ILC-like cell lines through multi-omic analysis to identify molecular similarities with patient tumors and potential therapeutic targets.

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.

TISON is a web-based platform for multi-scale cancer modeling that integrates biomolecular data and patient-specific information to support drug target discovery and personalized therapeutics.

This study develops an in silico Drosophila Patient Model to identify optimal combinatorial therapies for colorectal cancer using Boolean networks and patient-specific data.

This study sequenced 41 stage IV breast cancer samples using MammaSeq to identify 59 genomic alterations, including 49 SNVs and 10 CNVs, with 8 having clinical significance.