Justin Paul Kline

This study identifies conserved spatial structures in tumors that predict immune response, using a classification framework based on transcriptional covariation.

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

This study shows that enhancing Fas/FasL signaling improves CAR-T cell bystander killing against antigen-negative tumor cells, reducing antigen escape and improving therapeutic outcomes.

This study identifies two distinct waves of CD8+ CAR T-cell differentiation in DLBCL patients, showing they originate from different precursor populations with distinct phenotypes and ontogenies.

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.