Aurimas Kopūstas

This study investigates how S100A9 and alpha-synuclein form heterotypic droplets through LLPS and how this affects alpha-synuclein aggregation and fibril stability.

The paper reveals a beta-relay signaling mechanism in prokaryotic Argonautes that activates the SPARDA defense system to degrade invading DNA and host DNA, preventing plasmid spread.

This study compares alpha-synuclein aggregation under conditions that promote or negate liquid-liquid phase separation, showing that phase separation leads to more structurally variable and toxic fibrils.