Systems BiologyNature Structural & Molecular BiologyPeer-reviewed
Variant characterization in the intrinsically disordered human proteome
Dalmira Hubrich, Jesús Alvarado-Valverde, Chop Yan Lee…·Katja Luck
The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.
DOI 10.1038/s41594-026-01846-z