Evolutionary BiologyMolecular Biology and EvolutionPeer-reviewed
Cysteine enrichment mediates co-option of uricase in reptilian skin and transition to uricotelism
Giulia Mori, Anastasia Liuzzi, Luca Ronda…·Riccardo Percudani
This study identifies a cysteine-rich urate oxidase in chickens that retains urate oxidation but can also regenerate urate, suggesting a repurposed role in reptilian skin and uricotelism.