Massimo Vassalli

This study improves MSCs for HSCT by suppressing senescence and shows enhanced engraftment in an AML niche model.

This study shows that viscosity, not just elasticity, drives EMT in pancreatic intraepithelial neoplasia using hydrogel models.

The paper shows that cell loss in RPE cells leads to mechanical changes that impair function, mimicking age-related decline in an in vitro model.

This study investigates how nucleoli drive nuclear remodelling in cardiomyocytes during heart failure, showing NI loss precedes cytoskeletal stiffening and is linked to DNA damage and nucleolar changes.

This study shows that vascular stiffness promotes endothelial senescence and inflammation, identifying extracellular matrix as a therapeutic target for aging and chemotherapy-induced vascular dysfunction.

The paper develops a bioengineered bone marrow model that supports stem cells and mimics disease metabolism and chemotherapy effects, showing enhanced taurine metabolism and chemotherapy response.

The paper identifies and characterizes Cryptosporidium Oocyst Wall Proteins (COWPs), showing that COWP8 maintains the structural integrity of the oocyst wall without affecting viability or chlorination resistance.

The paper shows Piezo1 senses viscoelasticity in soft ECMs and identifies transcriptomic changes in MSCs in response to matrix properties and Piezo1 activity.

This study identifies biomechanical compartmentalization in the regenerating intestine and shows vascular Piezo1 influences angiogenesis and stem cell proliferation across species.

This study investigates how matrix viscoelasticity and spatial confinement influence epithelial cell mechanobiology and migration on soft and stiff substrates, revealing distinct effects on cell behavior.