Hassan Gharibi

This study uses multi-omics to uncover Gardnerella genomic features linked to biofilm formation and interspecies interactions in the vaginal microbiome, identifying potential therapeutic targets for bacterial vaginosis.

The paper introduces ThermoTargetMiner, a database that identifies protein targets of lung cancer therapeutics using the PISA assay, revealing novel targets for 77% of tested compounds.

HOLSER improves proteome coverage and depth for structural analysis of protein-ligand interactions and conformational changes.

The paper develops a transcriptomic-guided compound prioritization pipeline and validates it with proteomics, identifying two compounds that partially rescue HNRNPU deficiency phenotypes.

The paper improves target identification in chemical proteomics by using Fisher's method to aggregate peptide-level data instead of protein-level data.

The paper introduces AFDIP, a chemical proteomics method that identifies drug target binding sites with high structural resolution using digestion rate analysis and MD simulations.

This study demonstrates that Fourier Transform Isotopic Ratio Mass Spectrometry can reliably analyze isotope ratios from less than 10 ng of protein, enabling single-cell-scale stable isotope analysis.

The paper introduces KISSE, a statistical framework for species identification using bone collagen tandem mass spectrometry data, which provides species identification and probability estimates.

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

This study standardizes protein corona characterization across proteomics centers, improving data consistency and reproducibility through unified protocols and workflows.

This study shows that ultralight Caenorhabditis elegans, grown on isotopically depleted bacteria, have shorter lifespans despite faster growth and maturation.

This study simulates traumatic brain injury using a dummy head to generate g-force and shockwave, revealing proteome solubility changes and identifying shockwave as the main cause of irreversible cell damage.