Daniel Schultz

This study uses a dynamical model to show how antibiotic exposure dynamics select for different gene regulatory strategies in resistance.

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

This study shows temperate phages in V. cholerae biofilms can displace non-lysogenized bacteria but face spatial and immunity constraints that limit their competitive advantage.

This study analyzes 450 Pseudomonas aeruginosa isolates from CF patients to show structured population dynamics, migration, and parallel adaptive evolution within lung infections.

The paper tracks circadian clock protein dynamics in syncytia, revealing coordinated nuclear localization and subnuclear interactions across multiple nuclei.

This study quantifies pre-existing and drug-induced persisters using a framework combining kinetic modeling and SDTK assays, revealing antibiotic-specific persistence dynamics and a tolerance spectrum.

This paper identifies molecular changes in insulin analogs under stress and demonstrates antibody-based detection of fibrillation, highlighting the need for accessible insulin quality testing.

The paper models gene expression and growth dynamics during antibiotic exposure, showing that initial resource allocation variations predict divergent cell fates and survival outcomes.

This study shows that the dynamics of antibiotic exposure influence the type of mutations that evolve in bacteria, with gradual exposure leading to adaptive mutations and periodic exposure causing loss of regulatory control.

This study shows that Pseudomonas aeruginosa resistance to aminoglycosides is heterogeneous, with mexZ mutations improving survival by bypassing slow MexXY activation, and introduces a 'Response Dynamics' assay to measure resistance in fluctuating drug environments.

This study shows that biased dispersal of a dominant bacterial species prevents competitive exclusion, enabling coexistence in multispecies biofilms.

The paper constructs a dynamical model linking antibiotic resistance expression and metabolism to explain population heterogeneity during drug exposure in E. coli.

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

The paper develops a dynamical model to identify optimal gene regulation strategies for cellular responses to environmental shifts based on selective pressures.