This study identifies SAC competency as the determinant of sensitivity to KIF18A inhibition in SCLC, offering a predictive biomarker for targeted therapies.

DOI 10.1158/2767-9764.crc-26-0560

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 31, 2026

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

Amira Z Kazi, Yingying Cao, Chirayu Mohindroo…·Anish Thomas

DOI 10.64898/2026.07.30.741857

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 30, 2026

Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer

Brett Schroeder, Jae Choi, Alejandro A. Schäffer…·Anish Thomas

The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.

DOI 10.64898/2026.07.29.738916

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 1, 2026

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

Ajit Kumar Sharma, Nobuyuki Takahashi, Yingying Cao…·Anish Thomas

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

DOI 10.64898/2026.06.30.735617

humanbulk RNA-seq

𝕏 PostBluesky