Gerald J. Atkins

This study quantifies bone loss and histopathological changes in a mouse implant infection model, showing host-driven bone remodeling and correlations with bacterial:host genome ratios.

This study shows human osteocytes express MHC Class II and present antigens during bacterial infection, suggesting a new role in immune surveillance.

This study investigates TWEAK and Fn14 expression in human osteoarthritis cartilage and finds TWEAK induces RANKL release from chondrocytes.

This study shows Staphylococcus aureus can enter a viable-but-non-culturable state within osteocytes, escape, and revert to active growth, explaining culture-negative but PCR-positive osteomyelitis.

This study evaluates the effectiveness of antibiotics against intracellular S. aureus infections in osteocytes, finding limited efficacy even at high concentrations.

This study investigates how antibiotics and autophagy modulation affect intracellular Staphylococcus aureus persistence in osteocytes, finding that antibiotics inhibit autophagy but do not clear bacterial DNA.

This study demonstrates the discrepancy between colony-forming-unit and bacterial genome copy number in osteomyelitis and proposes an improved workflow for bacterial burden quantification in clinical specimens.