Mehmet Somel

This study analyzes ancient Iberian sheep genomes to show how human activities shaped their genetic diversity over 7,000 years, including maritime introduction, Steppe ancestry influx, and Roman-era expansion.

DeepKin predicts relatedness from low-coverage genomes and paleogenomes using CNNs, achieving accuracy >90% with 10K shared SNPs and outperforming READv2.

This study compares ancient DNA yields among ossicles and the petrous bone, finding the stapes has higher endogenous DNA preservation than the petrous bone.

The paper analyzes genetic data from Neolithic Catalhöyük to show changes in kinship patterns and persistent female roles over time.

This study uses 30 new palaeogenomes to show that Neolithic expansion into Western Anatolia involved both indigenous assimilation and eastern population influx, with cultural diversity decoupled from genetic differences.

This paper compares methods to reduce reference bias and postmortem damage in ancient genome data, finding that graph alignment and bamRefine improve accuracy and genotyped loci.

The paper identifies age-specific burial practices at Neolithic Catalhöyük by analyzing ancient DNA preservation differences between subadults and adults.

The paper analyzes ancient DNA from two Early Chalcolithic individuals from the West Mound, finding no close genetic kinship and no eastern gene flow signature.

The paper explains the sister repulsion phenomenon in Patterson's f-statistics by proposing a demographic model involving gene flow from an external source.

The paper investigates DNA methylation changes in ancient genomes to assess epigenetic impacts of the Neolithic transition but finds no systematic methylation differences related to diet or lifestyle.

The paper presents paleogenomes of three Anatolian equids from the 1st millennium BCE, identifying them as the extinct European wild ass, E. hydruntinus, and revealing genetic relationships and diversity loss.

This study benchmarks four kinship estimation tools for ancient genomes using simulated pedigrees and finds varying accuracy depending on the tool and SNP count.

This study analyzes the population history and genetic diversity of Anatolian and Cyprian mouflons compared to other sheep lineages, finding genetic affinity with domestic sheep and disparities in diversity and mutation load.

READv2 improves ancient DNA relatedness analysis by being faster, more accurate, and easier to use than previous methods.

CONGA genotypes copy number variants in ancient genomes and low-coverage data, showing coherent deletion frequencies and purifying selection across 50 ancient human genomes.

The paper examines somatic copy number variant (CNV) frequencies in neurons from Alzheimer's disease patients and healthy controls using low-coverage single-cell whole-genome sequencing, finding slightly higher CNV frequencies in AD patients but no statistically significant differences.

This study analyzes ancient genomes from Upper Mesopotamia during the Neolithic Transition, revealing genetic diversity, immigration, and cultural practices such as head-shaping.

MTaxi classifies closely related species from low coverage ancient DNA data using mitochondrial DNA substitutions, achieving 100% accuracy on tested samples.

The paper analyzes gene expression in multiple tissues across development and ageing in mice, finding that tissues converge in expression patterns with age, associated with loss of tissue identity.

This study shows inbreeding frequency decreased over time in ancient Eurasian populations, linked to population growth from agricultural practices.

This study shows that gene expression heterogeneity increases with aging in the human brain and is linked to lifespan regulation and neuronal functions.

The paper analyzes testis transcriptomes across primates to show convergent evolution linked to mating strategies, finding both tissue composition shifts and cell-autonomous changes.