Author

Lauren Veronica Albrecht

University of California SystemORCID 0000-0002-3147-8010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alijah Macapagal· 1 shared Angela Lackner· 1 shared Cody A. LoyiD· 1 shared Darci Jones TraderiD· 1 shared Eslam M.H. AliiD· 1 shared Hal M. HoffmaniD· 1 shared Hannah J. LeeiD· 1 shared Huilin XuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alijah Macapagal

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2 papers

Recent·Most cited

ImmunologyCommunications BiologyPeer-reviewedApr 16, 2026

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

Angela Lackner, Sofia I. Picucci, Wenjin Jiang…·Reginald McNulty

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

2 citations

humanproteomics

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BiochemistryJournal of Medicinal ChemistryPeer-reviewedApr 19, 2025

ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation

Cody A. Loy, Eslam M.H. Ali, Laurence J. Seabrook…·Darci Jones Trader

This paper introduces ByeTACs, bifunctional degraders that target proteins by interacting with the 26S proteasome instead of an E3 ligase, and shows they effectively degrade BRD4.

43 citationstop 1%

experimental assaydrug response / drug discovery

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