Dieter W. Heermann

This study introduces a polymer physics-based model integrating contact data and nucleosome positioning to reveal structural differences between active and inactive chromatin states in human genomic loci.

VECTOR quantifies chromatin structure from Hi-C data using Von Neumann entropy and graph spectral theory, outperforming existing tools in detecting structural changes across biological conditions.

The paper provides in vivo evidence that NAP-mediated chromosome re-modelling regulates transcription of the osmoresponsive proVWX operon in E. coli by destabilizing and re-establishing H-NS bridges under hyperosmotic conditions.

The paper proposes a self-organising model explaining how bacterial chromosomal origins are positioned and partitioned during the cell cycle, showing agreement with experimental data.