GeneticsbioRxivPreprint
A Most Powerful Test for Gene-Gene Interaction in the Presence of Main Effects
Razvan G. Romanescu, Xiaoqing Liu
The paper develops a statistically optimal test for gene-gene interaction that accounts for main effects, showing improved power over existing methods in simulations and identifying pathway-related SNP pairs in IBD data.
DOI 10.64898/2026.01.30.702572