Jeffrey D. Hartgerink

This study demonstrates growing macroscopic functional human tissues on 3D-printed peptide hydrogels, enabling centimeter-scale neural organoids and directional axonal communication.

This study investigates how interhelical interactions guide the assembly of collagen mimetic peptides into D-periodic fibrils, nanotubes, and nanosheets.

This study develops SABER hydrogels that extend drug release and therapeutic effect for small molecules and biologics in preclinical models.

This paper demonstrates that Dopa crosslinking with lysine covalently stabilizes collagen mimetic peptides and their assemblies, enhancing thermal stability for biomedical applications.

The paper designs collagenous assemblies using a peptide self-assembly system and solves their structure with cryo-EM, revealing a non-twisting triple helix conformation that differs from the canonical right-handed triple helix.

This study explores the sequence-structure relationship in collagen-like peptides, designing new peptides that form diverse quaternary structures beyond triple helices.

This paper conjugates a TLR7 agonist to a peptide hydrogel to create a vaccine adjuvant that produces antibody titers similar to alum and a more balanced Th1/Th2 immune response.

This paper designs a collagen heterotrimer with high folding specificity and reports its faster folding rate compared to other systems.

This study develops a method to create aligned peptide nanofibers and shows how their alignment affects hydrogel properties and cell behavior.