Rolf Zeller

This study identifies early transcriptional targets of WNT signaling during limb bud and digit development by transiently blocking WNT signaling with small molecule inhibitors.

This study identifies mesenchymal progenitors in mouse limb buds that regulate digit numbers and identities through BMP signaling and GREM1-mediated antagonism.

The paper identifies TBX3 as a key transcription factor for establishing the antero-posterior axis polarity in mouse limb buds by repressing anterior genes and up-regulating posterior genes with HAND2.

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

The paper identifies SMAD4 target genes and their role in integrating BMP and SHH signaling during early limb bud development, revealing opposing regulatory effects on anterior and posterior gene expression.

This study shows Gli3 and Hand2 work together to control gene expression in craniofacial development without relying on a graded Hh signal.

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.