Systems BiologybioRxivPreprint
Temporal perturbation of STAT1/2 activity reveals dynamic ligand discrimination of type I interferon signaling
Haowen Yang, Thomas van de Kreeke, Laura C. Van Eyndhoven, Jurjen Tel
The paper investigates how STAT1/2 activity differs in response to IFN and IFNβ through temporal perturbation, revealing distinct signaling dynamics and refractory states.
DOI 10.1101/2023.03.27.534340