Molecular BiologyNature CommunicationsPeer-reviewed
Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells
Mélanie Uguen, Devan J. Shell, Madhushika Silva…·Stephen V. Frye
The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.