Author

Johnson Ung

University of VirginiaORCID 0000-0002-3275-0530Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Arati K. SharmaiD· 3 shared David F. ClaxtoniD· 3 shared David J. FeithiD· 3 shared Jeremy J.P. ShawiD· 3 shared Myles C. Cabot· 3 shared Su‐Fern TaniD· 3 shared Thomas P. LoughraniD· 3 shared Todd E. FoxiD· 3 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Arati K. SharmaORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 6, 2025

Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response

Johnson Ung, Su‐Fern Tan, Jeremy J.P. Shaw…·Thomas P. Loughran

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

DOI 10.1101/2025.06.06.657881

humanbulk RNA-seq

𝕏 PostBluesky

Systems BiologyBlood AdvancesPeer-reviewedJan 3, 2024

Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes

B. Bishal Paudel, Su‐Fern Tan, Todd E. Fox…·Thomas P. Loughran

This study identifies two sphingolipidomic subtypes in AML, with one subtype associated with poor clinical outcomes and high-risk features.

10 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCancersPeer-reviewedDec 15, 2023

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Johnson Ung, Su‐Fern Tan, Todd E. Fox…·David J. Feith

This study evaluates the anti-leukemic effects of LCL-805, an acid ceramidase inhibitor, in AML cell lines and patient samples, showing it promotes iron-dependent cell death by antagonizing Akt signaling.

10 citations

humanbulk RNA-seq

𝕏 PostBluesky