Eugene A. Kapp

This paper presents a high-resolution cryo-EM structure of garadacimab Fab bound to βFXIIa, revealing its unique binding mechanism and insights into FXII inhibition in HAE.

The paper introduces PEFF, a new format for proteomics data that enhances FASTA with metadata for sequence variants and PTMs, enabling better analysis in proteogenomics and top-down proteomics.

MSCypher improves proteomics analysis by integrating database searching with machine learning to enhance identification rates and handle multiplexed spectra.