Masanobu Oshima

This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.

The paper shows TET2-mutant clonal hematopoiesis reduces cancer metastasis by preventing T-cell exhaustion through DNA methylation changes.

This study develops a 3D in vitro system to visualize tumor intravasation of CTC clusters and identifies TGF-β and activin signaling as essential for this process.

The paper investigates extravasation mechanisms in metastatic tumors using a 3D microvessel model and time-lapse imaging, revealing vascular remodeling as a key process in polyclonal colonization.