Author

Elise K. Phillips

Oak Ridge National LaboratoryORCID 0000-0002-3361-7475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:benchmarking· 2 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:C. elegans· 1 Organism:E. coli· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Carrie A. EckertiD· 2 shared Dawn M. KlingemaniD· 2 shared William G. AlexanderiD· 2 shared Adam M. GussiD· 1 shared Christelle F. AncajasiD· 1 shared Gregory A. PhelpsiD· 1 shared Jeffrey M. RybakiD· 1 shared Jemma McLeish· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSynthetic Biology

Carrie A. EckertORCID

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3 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintMay 23, 2025

When good guides go bad: empirical evaluation of all unique Cas9 targets in E. coli reveal widespread functionality and rules for gRNA design

Elise K. Phillips, Rick Harrison, S’Khaja Charles…·William G. Alexander

The paper evaluates nearly 500,000 unique gRNAs in E. coli, finding most are functional and identifying rules to improve gRNA design.

DOI 10.1101/2025.05.23.651106

E. coliCRISPR screen

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintMay 12, 2025

Multilayered regulation by RNA thermometers enables precise control of Cas9 expression

Elise K. Phillips, Dawn M. Klingeman, Adam M. Guss…·William G. Alexander

The paper demonstrates that RNA thermometers can reduce Cas9-induced cell death by controlling its expression through temperature-dependent regulation.

1 citation

CRISPR screenexperimental assay

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MicrobiologymBioPeer-reviewedApr 8, 2024

The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase

Yue Zhou, Gregory A. Phelps, Mikayla M. Mangrum…·T. B. B. Reynolds

The paper identifies CBR-5884 as a potent inhibitor of Candida albicans Cho1, showing fungistatic effects and disrupting in vivo Cho1 function.

11 citations

C. elegansexperimental assay

𝕏 PostBluesky