Mark A. Lemmon

The paper shows PH domains bind both phosphoinositides and negatively charged protein regions, expanding their regulatory roles beyond membrane targeting.

This study uses HDX-MS to analyze EGFR dynamics upon TKI binding, revealing inhibitor-dependent structural changes that correlate with side effects and covalent inhibitor selectivity.

This study identifies two mutation profiles in EGFR Exon-19 deletions that correlate with differential TKI sensitivity through analysis of conformational dynamics and solvent interactions.