John S. Klassen

This paper develops PD-L1-targeting macrocycle imaging agents using phage-display technology without non-canonical amino acids, achieving single-digit-nanomolar potency and structural characterization.

This study identifies how BcsZ cellulase processes phosphoethanolamine-modified cellulose in the periplasm, revealing stochastic pEtN distribution and independent BcsZ function.

The paper shows that the Q226H mutation in H5N1 hemagglutinin allows binding to human-type a2-6 sialic acid receptors, suggesting a path towards human adaptation.

This study investigates Siglec-6's binding mechanism to gangliosides, showing it relies on both conserved and membrane-associated residues for effective recognition.

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

This paper identifies 9-O-acetylated sialic acids as a ligand for the SARS-CoV-2 NTD, revealing a dual-receptor functionality in the S1 domain that was rapidly selected against.