Elisa Fadda

The paper integrates glycosylation filtering into a protein design pipeline to improve efficiency and reduce costs in binder design.

This study investigates how the terminal Glc-(1-2)- in the LLO donor affects OST catalytic efficiency through molecular dynamics simulations of yeast OST with and without this motif.

The paper shows that O-glycans in LRP1's ligand-binding domains differentially modulate uptake of tau and amyloid beta, but not RAP or ApoE.

This study investigates Siglec-6's binding mechanism to gangliosides, showing it relies on both conserved and membrane-associated residues for effective recognition.

This paper identifies sequence determinants that regulate oligosaccharyltransferase (OST) catalytic efficiency and glycosylation specificity in proteins.

This study identifies key residues in Siglec-10 involved in ligand recognition and shows that antibody blockade can restore CAR-T cell cytotoxicity.

This paper characterizes the glycosylation of soluble CD52 and identifies its role in immune suppression through interactions with HMGB1 and SIGLEC-10.

This study uses MD simulations to show that N99 glycosylation in ATG9A enhances protomer interactions and lipid scrambling, but does not significantly affect autophagy flux.

The paper introduces GlycoShape, an open-access database and tool to restore glycosylation to protein structures using molecular dynamics simulations and public structural data.

The paper introduces CandyCrunch, a deep learning model that predicts glycan structures from tandem mass spectrometry data with high accuracy, enabling high-throughput glycomics.

The paper creates a structural atlas of ASM variants to understand their pathogenic mechanisms and therapeutic implications.

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

The paper examines how natural variations in SARS-CoV-2 glycan sites affect spike protein dynamics and antigenic structure through molecular dynamics and structural modeling.