Maria Carmo‐Fonseca

The paper compares thick-filament protein ratios in iPSC-derived cardiomyocytes to adult and fetal heart proteomes, finding adult-like stoichiometry despite developmental immaturity.

This study maps alternative splicing dynamics during human cardiac development and identifies splicing markers in iPSC-derived cardiomyocytes, revealing both similarities and differences with native cardiac splicing patterns.

This study evaluates computational tools for predicting the functional impact of deep intronic variants, finding significant differences in performance and highlighting the trade-off between interpretability and predictive power.

This study uses NET-seq to analyze co-transcriptional splicing dynamics in Drosophila embryos, revealing differences in splicing timing and intron definition across developmental stages.

The paper introduces POINT technology to study co-transcriptional RNA processing, revealing insights into splicing kinetics, Xrn2 exonuclease specificity, and transcript termination mechanisms.