Author

William J. Ratzan

Harvard UniversityORCID 0000-0002-3426-2477Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandre TrappiD· 1 shared Amin HaghaniiD· 1 shared Andrei E. TarkhoviD· 1 shared Benjamin P. BarréiD· 1 shared Bohan ZhangiD· 1 shared Bradley James BakeriD· 1 shared Gwendolyn MuelleriD· 1 shared Heini M. MiettineniD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Alexandre TrappORCID

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2 papers

Recent·Most cited

BiophysicsThe Journal of General PhysiologyPeer-reviewedMay 8, 2024

S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing

Vamseedhar Rayaprolu, Heini M. Miettinen, William D. Baker…·Susy C. Kohout

This study shows that S1 hydrophobic residues in voltage sensing phosphatase (VSP) modulate voltage sensing and enzymatic activity by altering voltage dependence and kinetics.

3 citations

protein structureexperimental assay

𝕏 PostBluesky

GeneticsbioRxivPreprintAug 2, 2022

Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis

Bohan Zhang, Andrei E. Tarkhov, William J. Ratzan…·Vadim N. Gladyshev

The paper identifies gastrulation in Xenopus laevis as the stage with the lowest epigenetic age and highest developmental disruption, suggesting it as the onset of aging.

5 citations

DNA methylationstatistical model

𝕏 PostBluesky