Author

Arnaud Millet

Centre National de la Recherche ScientifiqueORCID 0000-0002-3547-7533Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pathology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Édouard GirardiD· 2 shared Fabienne ThomasiD· 2 shared Gaël S. RothiD· 2 shared Marie MalieriD· 2 shared Marie‐Hélène LaverrièreiD· 2 shared Angelique Stephanou· 1 shared Anthony SébillotiD· 1 shared Cécile ArellanoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersPathology

Édouard GirardORCID

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3 papers

Recent·Most cited

Systems BiologyMathematical Modelling of Natural PhenomenaPeer-reviewedJan 1, 2025

Spatial organization of mediated-macrophage chemoprotective niches in solid tumors: A mathematical analysis

William Dangelser, Angelique Stephanou, Arnaud Millet

This paper uses mathematical modeling to show that macrophage-driven protection against chemotherapy arises from spatially structured protective niches, not just biochemical degradation.

1 citation

statistical model

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PathologyCancer LettersPeer-reviewedOct 23, 2024

Tumor-associated macrophages confer resistance to chemotherapy (Trifluridine/Tipiracil) in digestive cancers by overexpressing Thymidine Phosphorylase

Marie Malier, Marie‐Hélène Laverrière, Maxime Henry…·Arnaud Millet

The paper shows that tumor-associated macrophages overexpress thymidine phosphorylase, leading to resistance to TAS-102 chemotherapy in digestive cancers.

6 citations

humanmouse

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ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedSep 1, 2024

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

Khaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier…·Arnaud Millet

This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.

28 citationstop 5%

humanproteomics

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