Ying-Chih Chuang

This study compares mutation accumulation in bacterial monocultures and cocultures, finding that cross-feeding can limit rather than promote metabolic dependencies.

The paper investigates whether metabolite externalization by bacteria is driven by toxicity to the producer or reciprocal benefit, finding that adenine externalization by Rhodopseudomonas palustris is likely a physiological response to its toxicity.

The paper identifies adenine as a cross-fed metabolite between Rhodopseudomonas palustris and E. coli, revealing a purine salvage bottleneck mechanism.