Julia Casado

Cyclic immunofluorescence of 265 high-grade serous ovarian carcinomas and random-forest feature ranking identify cancer-cell MHC-II as an adjusted predictor of longer survival marking immune-activated tumor-stroma hotspots.

Tribus is a semi-automated tool for cell phenotyping from multiplexed imaging and proteomic data, achieving high accuracy and efficiency compared to existing methods.

The paper introduces an interactive workflow called Cyto for analyzing mass cytometry data, demonstrating its ability to capture immune cell sub-populations and tumor compositions in blood and ovarian cancer samples.

This study identifies epigenetic inhibitors that enhance the effectiveness of immunochemotherapy in DLBCL by disrupting DNA repair and cell cycle pathways.