GenomicsbioRxivPreprint
A novel Bayesian factor analysis method improves detection of genes and biological processes affected by perturbations in single-cell CRISPR screening
1 citation
Author
Yifan Zhou
University of ChicagoORCID 0000-0002-3768-9353Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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2019-2022 · peak 1/yrCo-Author Collaboration Network
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Recent·Most cited
- GeneticsbioRxivPreprint
Multiple genes in cis mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neurons
Siwei Zhang, Hanwen Zhang, Marc P. Forrest…·Jubao Duan
The paper identifies multiple genes in cis regulated by a chromatin accessibility variant that contribute to synaptic dysfunction in human neurons associated with schizophrenia.
1 citation - GeneticsbioRxivPreprint
Allele-specific open chromatin in human iPSC neurons elucidates functional non-coding disease variants
Siwei Zhang, Hanwen Zhang, Min Qiao…·Jubao Duan
The paper identifies allele-specific open chromatin (ASoC) variants in human iPSC-derived neurons and shows their strong enrichment in brain disorder risk variants.