Savvas Kourtis

The paper identifies a metabolic vulnerability in TP53-deficient cells linked to nuclear adenosine metabolism and histone methylation, showing its role in DNA damage response and tumor growth.

This study identifies cell cycle-dependent nuclear phosphatidylinositol metabolism and its impact on histone methylation and heterochromatin states.

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

Machine learning integration of over 25,000 mass spectrometry experiments yields 15,326 human protein complexes covering 13,769 proteins, plus 511 AlphaFold-derived mutually exclusive subunit pairs.

The paper introduces a workflow for IP-MS data to detect differentially present bait proteoforms, offering insights into protein function through peptidoform analysis.

The paper identifies PRDX1 as essential for DNA damage repair by scavenging nuclear ROS and regulating aspartate synthesis during the DNA damage response.