Author

Gregory J. Brunette

Harvard UniversityORCID 0000-0002-3829-9031Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:Hi-C· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Cheng-Zhong ZhangiD· 3 shared Richard W. TourdotiD· 3 shared Adam Joel BassiD· 1 shared Agoston Agoston· 1 shared Alberto CicciaiD· 1 shared Ananya AcharyaiD· 1 shared Angelo TaglialatelaiD· 1 shared Chip StewartiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersGenomics

Cheng-Zhong ZhangORCID

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4 papers

Recent·Most cited

GenomicsCell SystemsPeer-reviewedMar 1, 2026

Haplotype-resolved reconstruction and functional interrogation of cancer karyotypes

Gregory J. Brunette, Richard W. Tourdot, Jinyu Wang…·Cheng-Zhong Zhang

This paper introduces refLinker, a method for haplotype-resolved analysis of cancer karyotypes, revealing transcriptional consequences of somatic Xi rearrangements.

5 citations

humanHi-C

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GenomicsGenome biologyPeer-reviewedMay 6, 2021

Determination of complete chromosomal haplotypes by bulk DNA sequencing

Richard W. Tourdot, Gregory J. Brunette, Ricardo A. Pinto, Cheng‐Zhong Zhang

This paper presents a computational method to determine complete chromosomal haplotypes using bulk long-range sequencing and Hi-C data, achieving high precision and completeness in diploid human genomes.

39 citations

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintMar 26, 2021

Genomic signatures of past and present chromosomal instability in the evolution of Barretts esophagus to esophageal adenocarcinoma

Matthew D. Stachler, Chunyang Bao, Richard W. Tourdot…·Cheng‐Zhong Zhang

This study identifies genomic signatures of chromosomal instability in Barrett's esophagus progressing to esophageal adenocarcinoma, showing sloping copy-number variation as a precursor to complexity.

7 citations

humanwhole-genome sequencing

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GeneticsbioRxivPreprintSep 3, 2019

Identification of MCM8IP, an interactor of MCM8-9 and RPA1 that promotes homologous recombination and DNA synthesis in response to DNA damage

Jen‐Wei Huang, Angelo Taglialatela, Ananya Acharya…·Alberto Ciccia

This study identifies MCM8IP as a DNA repair factor that promotes homologous recombination and DNA synthesis in response to DNA damage by interacting with MCM8-9 and RPA1.

1 citation

humanexperimental assay

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