John D. Helmann

This study shows that Bacillus subtilis requires bicarbonate for anabolic processes and that CO2 can be used as a substrate when endogenous CO2 production is increased.

This study identifies RpdA as an accessory protein required for PBP4 localization and activity in Bacillus subtilis, contributing to antibiotic resistance and PG synthesis.

This study identifies a novel mechanism by which rifampin shortens TB treatment by inhibiting Mtb RNA polymerase, leading to cell division arrest and reduced antibiotic resistance.

This study identifies a Cu(II) exchange mechanism between YcnI and YcnJ in B. subtilis, showing their roles in copper acquisition and regulation under copper limitation.

This study determines the structural basis of MntR-mediated gene activation through cooperative DNA binding using cryo-EM and complementary assays.

This paper shows that deletion of the yqgC-sodA operon in Bacillus subtilis causes Mn sensitivity by reducing Mn efflux and inhibiting Mg-dependent enzymes, distinct from efflux-deficient mutants.

This paper shows that the ytpAB operon, induced by cell wall inhibitors, helps Bacillus subtilis resist bacitracin by modulating membrane properties and interacting with resistance proteins.