Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewed
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues
Muhammad Murtaza Hassan, Yen-Der Li, Michelle W. Ma…·Nathanael S. Gray
This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.
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