Author

Yen-Der Li

Broad InstituteORCID 0000-0003-4753-7422Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam S. FischiD· 1 shared Anna M. SchmokeriD· 1 shared Annette S. KimiD· 1 shared Benjamin L. EbertiD· 1 shared Brian J. GroendykeiD· 1 shared Brittany SandovaliD· 1 shared Cyrus Y. JiniD· 1 shared Daniel SinnettiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Adam S. FischORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedSep 23, 2024

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

Muhammad Murtaza Hassan, Yen-Der Li, Michelle W. Ma…·Nathanael S. Gray

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

45 citationstop 3%

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJul 29, 2022

Outlier expression of isoforms by targeted RNA sequencing as clinical markers of genomic variants in B lymphoblastic leukemia and other tumor types

Harrison Kwei Tsai, Tasos Gogakos, Va Lip…·Marian H. Harris

The paper identifies outlier RNA isoform expression as a method to detect clinically relevant genomic variants in B-ALL and other cancers with high sensitivity and specificity.

2 citations

humanbulk RNA-seq

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