Christian Wolfrum

This study identifies methylene blue as a modulator of G3BP1 condensation that reduces preneoplastic lesions in Kras-driven pancreatic cancer models.

This study identifies TRIM21 as a regulator of BiP phase state under ER stress, preventing solidification and maintaining UPR function, with implications for pancreatic cancer.

This study shows that GPR180 deficiency impairs mitochondrial function and first-phase insulin secretion in pancreatic β-cells without affecting insulin sensitivity.

The paper constructs a transcriptomic BMI model to identify molecular differences between metabolically healthy and unhealthy obesity in humans and validates it in mice.

This study identifies Slit3 fragments that coordinate neurovascular expansion and thermogenesis in brown adipose tissue by regulating angiogenesis and sympathetic innervation.

The paper shows that hepatic GCGR is essential for the enhanced weight loss and lipid clearance effects of a dual GCGR/GLP1R agonist compared to a selective GLP1R agonist.

The paper investigates how maternal thyroid hormone exposure affects DNA methylation at a leptin upstream enhancer in adipose tissue, with sex-specific impacts on body fat percentage.

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

This study identifies AATBC as a human-specific lncRNA that regulates adipocyte plasticity and mitochondrial function, linking it to metabolic health.